Amodis
Metronidazole BP
Pharmacology:
Amodis (Metronidazole) a nitroimidazole has an extermely broad spectrum antiprotazoal and antimicrobial activities, with high activity against anaerobic bacteria and protozoa.Amodis(Metronidazole) is usually completely and rapidly absorbed after oral administration.The half-lic=fe in plasma is about 8 hours.About 10% of the drug is bound to plasma proteins.Amodis (Metronidazole)penetrates well into body tissues and fluids.The liver is the main site of metabolism.Both unchanged Metronidazole and metabolites are excreted in various proportions in the urine after oral administration.
Indication
All forms of amoebiasis(intestinl and extra-intestinal disease including liver abscess and that of symptomless cyst passers)*Trichomoniasis*Giardiasis*Bacterial vaginosis*Acute ulcerative*ginvitis*Anaerobic infections including septicaemia,bacteraemia,peritonitisbrain abscess,necrotising pneumonia,ostemyelitis,puerperal sepsis,pelvic absess,pelvic cellultis etc.
*Anaerobically-infected leg ulcers and pressure sores*Acute dental infections9e.g.acute pericoronitis and acute apical infections)*Surgical prophylxix(prevention of postoperative infections due to anaerobic bacteria,particulary species of bacteroides and anaerobic streptococci.*Chronic symptomatic peptic ulcer disease(as an agent of triple therapy to eradicate H.pylori-the most important aetiological factor of peptic ulcer)
Adverse Reaction
Metalic taste,furred tongue,nausea,vomition,diarrhoea,drowsiness,rashes and milt reversible leucopenia may be observed during treatment.
Drug Interaction
Metronidazole interacts with warfarin,nicoumalone,phenytoin,phenobarbitonefluorouracil,disulfiram,lithium,cimetidine etc,
Pregnancy & Lactation
Not recommended during first & later trimesters.breast feeding should be delayed until 48 hours after discontinuing. metronidazole in the mother.